CORRELATION OF MITRAL E- POINT SEPTAL SEPARATION WITH LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS OF ACUTE CORONARY SYNDROME

Abstract

Background: Acute Coronary Syndrome (ACS) is a major cause of morbidity and mortality worldwide and requires rapid assessment of left ventricular (LV) function for risk stratification. Left Ventricular Ejection Fraction (LVEF) is a key prognostic indicator but may not always be quickly measurable in emergency settings. E-point septal separation (EPSS), a simple M-mode echocardiographic parameter, has emerged as a rapid bedside surrogate for assessing LV systolic function.Aim: To determine the correlation between mitral E-point septal separation (EPSS) and left ventricular ejection fraction (LVEF) in patients with ACS.Methods: This observational study was conducted on 100 patients diagnosed with ACS at Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, between July 2024 and January 2026. EPSS was measured using M-mode echocardiography in the parasternal long-axis view, and LVEF was assessed using standard echocardiographic methods. Statistical analysis was performed to evaluate the correlation between EPSS and LVEF.Results: The majority of patients were males (71%) and aged 61–80 years (49%). STEMI was the most common presentation (48%). EPSS >7 mm was observed in 84% of patients. Most patients had moderately reduced LVEF (51%). A statistically significant inverse correlation was found between EPSS and LVEF (r = −0.602, p < 0.001), indicating that higher EPSS values are associated with lower LVEF. Additionally, EPSS showed significant association with BNP levels (p = 0.0477), reflecting its utility in assessing cardiac dysfunction.Conclusion: EPSS is a simple, rapid, and reliable bedside echocardiographic parameter that correlates significantly with LVEF in ACS patients. It can serve as a useful screening tool for early identification of LV systolic dysfunction, especially in emergency settings where quick decision-making is essential.