Frequency of multi drug resistant (MDR) Proteus species in clinical sample at tertiary care hospital.

Abstract

Background: Multidrug-resistant (MDR) Proteus species are becoming significant hospital-related pathogens linked to infections in wounds, the urinary tract, and the bloodstream. The rise of antimicrobialresistance restricts treatment choices and presents a significant clinical hurdle.Methods: A cross-sectional study was performed involving 37 unique MDR Proteus isolates collected from different clinical specimens. Species identification and antimicrobial resistance testingwere conducted using conventional microbiological techniques.Results: Out of 59 Proteus isolates 45 (76.6%) were Proteus mirabilis followed by 14 (23.7%) Proteus vulgaris. Out of 37 MDR of Proteus species isolates, Proteus mirabilis comprised 32 (86.5%) and Proteus vulgaris represented 5 (13.5%). Most cases were observed in patients older than 60 years (45.9%),with a higher prevalence in males (64.9%). Pus samples made up 56.8% of the isolates. Significant resistance was noted to cefepime (94.6%), ceftazidime (78.4%), and cefoperazone–sulbactam (70.3%). The resistance rate to piperacillin-tazobactam stood at 59.5%.Conclusion: P. mirabilis, are found leading factor to wound and systemic infections, exhibiting substantial resistance among the proteus species againstcephalosporins. Ongoing monitoring and proper use of antimicrobials are crucial for managing their dissemination.